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KMID : 1200020110350020091
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Diabetes & Metabolism Journal
2011 Volume.35 No. 2 p.91 ~ p.100
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The Importance of Global Studies of the Genetics of Type 2 Diabetes
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McCarthy Mark I.
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Abstract
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Genome wide association analyses have revealed large numbers of common variants influencing predisposition to type 2 diabetes and related phenotypes. These studies have predominantly featured European populations, but are now being extended to samples from a wider range of ethnic groups. The transethnic analysis of association data is already providing insights into the genetic, molecular and biological causes of diabetes, and the relevance of such studies will increase as human discovery genetics increasingly moves towards sequencing-based approaches and a focus on low frequency and rare variants.
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KEYWORD
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Diabetes mellitus, type 2, Fine-mapping, Genetics, Genome-wide association, Multiethnic, Resequencing, Transethnic
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